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Publications related to nutrition & lifestyle changes for kidney disease.

Newest publications listed on top.

Read scientific publications to learn about the science underlying KetoCitra and the Ren-Nu program.

Send these papers to your doctor if they are unfamiliar.

Messing, Melina, Jacob A. Torres, Nickolas Holznecht, and Thomas Weimbs.
Trigger Warning: How Modern Diet, Lifestyle, and Environment Pull the Trigger on Autosomal Dominant Polycystic Kidney Disease Progression.
Nutrients 16, no. 19 (January 2024): 3281.
https://doi.org/10.3390/nu16193281.

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Torres, J. A.; Holznecht, N.; Asplund, D. A.; Kroes, B. C.; Amarlkhagva, T.; Haeffner, M. M.; Sharpe, E. H.; Koestner, S.; Strubl, S.; Schimmel, M. F.; Kruger, S.; Agrawal, S.; Aceves, B. A.; Thangaraju, M.; Weimbs, T.
β-Hydroxybutyrate Recapitulates the Beneficial Effects of Ketogenic Metabolic Therapy in Polycystic Kidney Disease.
iScience 27, no. 9 (September 20, 2024).
https://doi.org/10.1016/j.isci.2024.110773.

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Athinarayanan, Shaminie J., Caroline G. P. Roberts, Chandan Vangala, Greeshma K. Shetty, Amy L. McKenzie, Thomas Weimbs, and Jeff S. Volek.
The Case for a Ketogenic Diet in the Management of Kidney Disease.
BMJ Open Diabetes Research & Care 12, no. 2 (April 27, 2024): e004101
https://doi.org/10.1136/bmjdrc-2024-004101

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Torres, Jacob A., Nickolas Holznecht, David A. Asplund, Tselmeg Amarlkhagva, Bradley Kroes, Juliette Rebello, Shagun Agrawal, and Thomas Weimbs.
A Combination of SS-Hydroxybutyrate and Citrate Ameliorates Disease Progression in a Rat Model of Polycystic Kidney Disease.
American Journal of Physiology. Renal Physiology 326 (December 14, 2023): F352–68
https://doi.org/10.1152/ajprenal.00205.2023

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Weimbs, Thomas, Jessianna Saville, and Kamyar Kalantar-Zadeh.
Ketogenic Metabolic Therapy for Chronic Kidney Disease - The Pro Part.
Clinical Kidney Journal 17(1), no. sfad273 (2023): sfad273.
https:/doi.org/10.1093/ckj/sfad273

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Cukoski, S.; Lindemann, C. H.; Arjune, S.; Todorova, P.; Brecht, T.; Kühn, A.; Oehm, S.; Strubl, S.; Becker, I.; Kämmerer, U.; Torres, J. A.; Meyer, F.; Schömig, T.; Hokamp, N. G.; Siedek, F.; Gottschalk, I.;
Benzing, T.; Schmidt, J.; Antczak, P.; Weimbs, T.; Grundmann, F.; Müller, R.-U.
Feasibility and Impact of Ketogenic Dietary Interventions in Polycystic Kidney Disease: KETO-ADPKD—a Randomized Controlled Trial.
Cell Reports Medicine (2023), 4 (11), 101283.
https://doi.org/10.1016/j.xcrm.2023.101283

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Cukoski, S.; Kühn, A.; Lindemann, C. H.; Arjune, S.; Meyer, F.; Schömig, T.; Große-Hokamp, N.; Schmidt, J.; Antczak, P.; Weimbs, T.; Grundmann, F.; Mueller, R.-U.
Ketosis Moderates the Effect on Kidney Volume in Dietary Interventions for ADPKD—More Insights on the KETO ADPKD Trial.
Nephrology Dialysis Transplantation (2024), 39 (Supplement_1), gfae069-0738–2160.
https://doi.org/10.1093/ndt/gfae069.738

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Oehm, S.; Steinke, K.; Schmidt, J.; Arjune, S.; Todorova, P.; Heinrich Lindemann, C.; Wöstmann, F.; Meyer, F.; Siedek, F.; Weimbs, T.; Müller, R.-U.; Grundmann, F.
RESET-PKD: A Pilot Trial on Short-Term Ketogenic Interventions in Autosomal Dominant Polycystic Kidney Disease.
Nephrology Dialysis Transplantation (2023), 38 (7), 1623–1635.
https://doi.org/10.1093/ndt/gfac311

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Bruen DM, Kingaard JJ, Munits M, Paimanta CS, Torres JA, Saville J, Weimbs T. 
Ren.Nu, a Dietary Program for Individuals with Autosomal-Dominant Polycystic Kidney Disease Implementing a Sustainable, Plant-Focused, Kidney-Safe, Ketogenic Approach with Avoidance of Renal Stressors.
Kidney and Dialysis (2022) 2:183-203

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Strubl S, Oehm S, Torres JA, Grundmann F, Haratani J, Decker M, Vuong S, Bhandal AK, Methot N, Haynie-Cion R, Meyer F, Siedek F, Korst U, Müller RU, Weimbs T. Ketogenic Dietary Interventions in Autosomal-Dominant Polycystic Kidney Disease (ADPKD)– A Retrospective Case Series Study: First insights into Feasibility, Safety and Effects.
Clinical Kidney Journal (2021) 15:1079-1092

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Torres, J. A.; Rezaei, M.; Broderick, C.; Lin, L.; Wang, X.; Hoppe, B.; Cowley, B. D.; Savica, V.; Torres, V. E.; Khan, S.; Holmes, R. P.; Mrug, M.; Weimbs, T.
Crystal Deposition Triggers Tubule Dilation That Accelerates Cystogenesis in Polycystic Kidney Disease.
J Clin Invest (2019), 129 (10), 4506–4522.
https://doi.org/10.1172/JCI128503

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Torres, J. A.; Kruger, S. L.; Broderick, C.; Amarlkhagva, T.; Agrawal, S.; Dodam, J. R.; Mrug, M.; Lyons, L. A.; Weimbs, T.
Ketosis Ameliorates Renal Cyst Growth in Polycystic Kidney Disease.
Cell Metab (2019), 30 (6), 1007-1023.e5.
https://doi.org/10.1016/j.cmet.2019.09.012

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